Structures, Signs, and Voids offers the first comprehensive monographic study of Leonardo Mosso and Laura Castagno-Mosso in over forty years, highlighting their distinctive position beyond Italy’s dominant postmodern narratives. Their work forms an original synthesis of emerging computer technologies, philosophical and political inquiry, and a linguistic exploration of structural nodes. Far from being limited to its historical moment, their research anticipates today’s discussions on digital tools in architecture, often constrained by efficiency-driven approaches. Central to their contribution is a dual commitment to computational experimentation and a radical vision for social and political transformation. Their relevance extends well beyond national boundaries, as demonstrated by exchanges with Nove Tendencije, Alvar Aalto, and Konrad Wachsmann, underscoring the European and international scope of their architectural thought.